公开(公告)号：US20100279976A1

公开(公告)日：2010-11-04

申请号：US12769263

申请日：2010-04-28

申请人： Hui Wang ,  Tao Chen ,  Junmei Hou ,  Mian Li

发明人： Hui Wang ,  Tao Chen ,  Junmei Hou ,  Mian Li

IPC分类号： A61K31/7068 ,  A61K31/366 ,  A61P35/00 ,  A61P15/00 ,  A61P1/16

CPC分类号： A61K31/555 ,  A61K31/357 ,  A61K31/366 ,  A61K31/7068 ,  A61K45/06 ,  A61K2300/00

摘要： A method for treating cancer in a mammal includes administering to the mammal in need thereof a therapeutically effective amount of artemisinin (ART) or its derivative, such as dihydroartemisinin (DHA), artemether (ARM), or artesunate (ARS) alone or in combination with a chemotherapeutic agent, such as gemcitabine and carboplatin. A method for inhibiting tumor cell proliferation includes contacting a tumor cell with ART or its derivative, such as DHA, ARM, and ARS, in an amount effective to inhibit tumor cell proliferation or in combination with a chemotherapeutic agent, such as gemcitabine and carboplatin.

摘要翻译： 用于治疗哺乳动物癌症的方法包括向有需要的哺乳动物施用单独或组合的治疗有效量的青蒿素（ART）或其衍生物，例如二氢青蒿素（DHA），蒿甲醚（ARM）或青蒿琥酯（ARS） 与化疗剂，如吉西他滨和卡铂。 抑制肿瘤细胞增殖的方法包括以有效抑制肿瘤细胞增殖的量或与化疗药物如吉西他滨和卡铂组合的方式使肿瘤细胞与ART或其衍生物如DHA，ARM和ARS接触。