公开(公告)号：US20080081081A1

公开(公告)日：2008-04-03

申请号：US11802527

申请日：2007-05-23

申请人： Hyeong Lee ,  Sei Oh ,  Kyung Ahn ,  Soon Choi ,  Jung Kim ,  Goo Oh ,  Jung Hong ,  Seong Park ,  Woo Namkung

发明人： Hyeong Lee ,  Sei Oh ,  Kyung Ahn ,  Soon Choi ,  Jung Kim ,  Goo Oh ,  Jung Hong ,  Seong Park ,  Woo Namkung

IPC分类号： A61K36/532 ,  A61P29/00

CPC分类号： A61K36/532 ,  A23L33/105 ,  A23L33/11

摘要： This invention includes a composition of Agastache rugosa and tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, an extract of Agastache rugosa and tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in the circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement systems as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.

摘要翻译： 本发明包括通过用于抗炎和抗动脉粥样硬化的分离纯化获得的藿香粗提物和斜霉素的组合物，更具体地，通过分离纯化从其获得的藿香提取物和斜霉素提取物，其不仅有效预防和治疗 炎症性疾病，而且与由动脉粥样硬化引起的循环系统中的炎性反应和疾病有关的动脉粥样硬化，因为它们作为炎症反应因子抑制补体系统的活性，细胞间粘附分子-1（ICAM-1）和 血管细胞粘附分子-1（VCAM-1）和一氧化氮（NO）的产生。 它们还可以显着减少由于炎症反应引起的动脉粥样硬化的发展。