公开(公告)号：US06458934B1

公开(公告)日：2002-10-01

申请号：US09438954

申请日：1999-11-12

申请人： Hyo Jeong Hong ,  Sung Sup Park ,  Young Jun Kang ,  Chang-Yuil Kang ,  Sung Kwan Yoon

发明人： Hyo Jeong Hong ,  Sung Sup Park ,  Young Jun Kang ,  Chang-Yuil Kang ,  Sung Kwan Yoon

IPC分类号： C07K1618

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

摘要： The present invention is directed to humanized antibodies that specifically bind the protein 4-1BB. The antibodies can be made by grafting of the complementarity determining regions (CDR's) of mouse monoclonal antibody to human 4-1BB to the remaining portions of a human antibody and by making further amino acid replacements. In addition, a pharmaceutical composition that includes the humanized antibody can be made and can be used to treat autoimmune diseases to suppress an immune response. The humanized antibody of the invention has high affinity for human 4-1BB, and exhibits sequence similarity to human antibody. As a result, the pharmaceutical composition of the present invention can be used to treat autoimmune disease and act as an immunosuppressant in humans without much side-effect.

摘要翻译： 本发明涉及特异性结合蛋白4-1BB的人源化抗体。 可以通过将小鼠单克隆抗体的互补决定区（CDR）与人4-1BB接枝到人抗体的其余部分并进一步进行氨基酸替换来制备抗体。 此外，可以制备包含人源化抗体的药物组合物，并且可以用于治疗自身免疫疾病以抑制免疫应答。 本发明的人源化抗体对人4-1BB具有高亲和力，与人抗体具有序列相似性。 结果，本发明的药物组合物可以用于治疗自身免疫性疾病，并且在人体中作为免疫抑制剂没有太多的副作用。