公开(公告)号：US20240316020A1

公开(公告)日：2024-09-26

申请号：US18665797

申请日：2024-05-16

申请人： ICAGEN, LLC ,  HOFFMANN-LA ROCHE INC.

发明人： Mark CHAPMAN ,  Nicholas Gareth Morse DAVIES ,  Aaron GERLACH ,  Sylvain LEBRETON ,  Ingrid MECHIN ,  David MOWREY ,  Karthigeyan NAGARAJAN ,  Anil NAIR ,  Roger David NORCROSS ,  Roger Lluis REDONDO PENA ,  Alena SAFAROVA ,  Martin SMRCINA

IPC分类号： A61K31/4439 ,  A61K9/20 ,  A61K31/443 ,  A61K31/4433 ,  C07D213/38 ,  C07D213/64 ,  C07D405/12 ,  C07D405/14

CPC分类号： A61K31/4439 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/443 ,  A61K31/4433 ,  C07D213/38 ,  C07D213/64 ,  C07D405/12 ,  C07D405/14

摘要： The invention provides new heterocyclic compounds having the general formula (I), or a solvate or a pharmaceutically acceptable salt thereof:




wherein R1, R2, R3, R4, R5, R6 and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240336571A1

公开(公告)日：2024-10-10

申请号：US18749828

申请日：2024-06-21

申请人： ICAGEN, LLC ,  HOFFMANN-LA ROCHE INC.

发明人： Mark CHAPMAN ,  Nicholas Gareth Morse DAVIES ,  Aaron GERLACH ,  Christopher John GRAHAM ,  Sylvain LEBRETON ,  Ronghua LI ,  Nina MA ,  Daniel MADDOX ,  Ingrid MECHIN ,  David MOWREY ,  Karthigeyan NAGARAJAN ,  Anil NAIR ,  Roger David NORCROSS ,  Roger Lluis REDONDO PENA ,  Alena SAFAROVA ,  Martin SMRCINA

IPC分类号： C07D221/00 ,  A61K31/4433 ,  A61K31/4439 ,  C07D239/26 ,  C07D401/04 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04

CPC分类号： C07D221/00 ,  A61K31/4433 ,  A61K31/4439 ,  C07D239/26 ,  C07D401/04 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04

摘要： The invention provides new heterocyclic compounds having the general formula (I′), or a solvate or a pharmaceutically acceptable salt thereof:






wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.