公开(公告)号：US20180162922A1

公开(公告)日：2018-06-14

申请号：US15833778

申请日：2017-12-06

Applicant: IMMATICS BIOTECHNOLOGIES GMBH

Inventor： SEBASTIAN BUNK ,  DOMINIK MAURER ,  JENS FRITSCHE ,  CLAUDIA WAGNER ,  LEONIE ALTEN ,  FRANZISKA HOFFGAARD ,  MATHIAS FERBER

IPC: C07K14/725 ,  C12N5/0783 ,  A61K35/17

Abstract: The present invention relates to modified T cell receptor (TCR) α or β chains, or heterodimers comprising the same, wherein in the variable domain of said modified α or β chain, an amino acid at position 44 according to the IMGT numbering is substituted by another suitable amino acid in order to improve pairing of desired chains.