公开(公告)号：US20230355678A1

公开(公告)日：2023-11-09

申请号：US18312144

申请日：2023-05-04

Applicant: IMMATICS US, INC.

Inventor： Pooja MEHTA ,  Rene TAVERA ,  Christopher LANIER ,  Mamta KALRA

IPC: A61K35/17 ,  C12N5/0783

CPC classification number: A61K35/17 ,  C12N5/0636 ,  C12N2501/999

Abstract: Methods of manufacturing T cells to improve their efficacy, persistence, memory function, and/or antigen stimulated survival are provided. Methods of manufacturing T cells to improve production of Central Memory T (Tcm) cells are provided. Methods may include culturing or treating T cells with one or more histone deacetylase inhibitor (HDACi) and interleukin-21 (IL-21), with one or more kinase inhibitor, such a tyrosine kinase inhibitor, and/or with one or more AKT inhibitor (AKTi).