公开(公告)号：US20230348561A1

公开(公告)日：2023-11-02

申请号：US18309062

申请日：2023-04-28

Applicant: IMMATICS US, INC.

Inventor： Erik FARRAR ,  Justin GUNESCH ,  Melinda MATA ,  Mohammad HOSSAIN ,  Mamta KALRA ,  Gagan BAJWA

IPC: C07K14/725 ,  C07K14/705 ,  C12N15/63 ,  A61P37/04

CPC classification number: C07K14/7051 ,  C07K14/70517 ,  C12N15/63 ,  A61P37/04

Abstract: The present disclosure relates to T cells capable of co-expressing T cell receptors (“TCR”) together with dominant negative TGFβ Receptor (“dnTGFβR”) polypeptides and/or CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for dnTGFβR polypeptides, vectors, and associated methods thereof. The present disclosure further provides for modified CD8 polypeptides, vectors, and associated methods of making and using the same.