公开(公告)号：US20130158101A1

公开(公告)日：2013-06-20

申请号：US13761444

申请日：2013-02-07

Applicant: IMMUNE DISEASE INSTITUTE, INC.

Inventor： Anjana Rao ,  Patrick Hogan ,  Sonia Sharma

IPC: A61K31/713

CPC classification number: A61K31/713 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y306/01

Abstract: Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of proteins involved in the calcineurin/NFAT axis.

Abstract translation: 本发明的实施方案涉及通过抑制参与钙调神经磷酸酶/ NFAT轴的蛋白质的表达或活性来调节NFAT活性，调节储存操作的Ca 2+进入细胞并治疗和/或预防多动症或不适当的免疫应答。