公开(公告)号：US20230310634A1

公开(公告)日：2023-10-05

申请号：US17920445

申请日：2021-04-22

申请人： IMMUNEXT, INC.

发明人： Jay Rothstein ,  Kierstin Bell ,  Catherine Carriere ,  Michael Molloy ,  Anna Kuta ,  Nicholas Schwertner ,  Maria Day ,  Xin Huang ,  Dov Pechenick ,  Toni Kline ,  Shibhani Rajanna ,  Yalin Guo ,  Yingcai (Ian) Wang ,  Jieyu Zhou ,  Sergey Seregin ,  Erin Clark ,  Labros Memetis ,  Julio Medina ,  Sheng Sun ,  Alexander Koval ,  Sravan Thummanapelli ,  Dmitry Borkin ,  Rajeshkumar Maganlal Loriya

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61P31/14 ,  A61P11/06 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K47/6849 ,  A61K47/6889 ,  A61K47/6803 ,  C07K16/2827 ,  A61P31/14 ,  A61P11/06 ,  A61P35/00 ,  A61P37/00 ,  C07K2317/94 ,  C07K2317/52 ,  A61K2039/505

摘要： The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.