专利检索 ap:("INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY" OR "KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY") AND inv:"Dong Hyun LEE" 第 1 页

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发明申请
RECOMBINANT VECTOR AND METHOD FOR PRODUCING RECOMBINANT FIBROBLAST GROWTH FACTOR 19 USING THE SAME 有权

公开(公告)号：US20210355182A1

公开(公告)日：2021-11-18

申请号：US16997198

申请日：2020-08-19

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY

发明人： Geun Joong KIM , Hye Ji CHOI , Dae Eun CHEONG , Su Kyoung YOO , Dong Hyun LEE , Jae Hong PARK , Jung Hyun LEE , Hyung Soon YIM , Young Jun AN , Kyeong Won LEE

IPC分类号： C07K14/50 , C12N9/90 , A61K38/00

摘要： A recombinant vector according to an embodiment of the present invention may produce fibroblast growth factor 19 (FGF19) having enhanced solubility. The synonymous codon substitution variant fibroblast growth factor 19 (scvhFGF19) and chaperone ΔssDsbC may be simultaneously and independently expressed in a host cell into which the recombinant vector is introduced, thereby it is possible to overexpress the fibroblast growth factor 19 in a soluble state, due to when not utilizing tags such as an existing fusion partner there is no change in the amino acid, which is a problem generated in the removal process.