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1.发明申请公开(公告)号：US20220154251A1
公开(公告)日：2022-05-19
申请号：US17454980
申请日：2021-11-15
Inventor： Dong Min KIM , You Mi LEE , Choon Mee KIM
Abstract: This application relates to a composition for diagnosis of leptospirosis and a method for diagnosis of leptospirosis by real-time PCR. For example, the application relates to a pair of primers of SEQ ID NOS: 1 and 2 and a probe of SEQ ID NO: 3, a kit for diagnosis of leptospirosis, comprising the diagnostic composition, and a method for providing information for diagnosis of leptospirosis are provided. The composition and the method can specifically detect L. interrogans IS 1500 gene and exhibit excellent accuracy and sensitivity, compared to conventional well-known detection methods. Thus, the simple method through real-time PCR using the composition allows the quick and accurate diagnosis of leptospirosis.
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公开(公告)号：US20220235399A1
公开(公告)日：2022-07-28
申请号：US17606723
申请日：2020-04-21
Inventor： Dong Min KIM
IPC: C12Q1/689 , G01N33/569
Abstract: A novel use of P44 as a marker for predicting or diagnosing anaplasmosis including a diagnostic composition and a diagnostic kit is disclosed. A diagnostic composition for anaplasmosis containing a P44 gene, a primer set or probe for detecting Anaplasma phagocytophilum, a kit for diagnosing anaplasmosis, and a method for providing information to diagnose infection with Anaplasma phagocytophilum are also disclosed. P44, which is a novel biomarker for diagnosing anaplasmosis, is a multi-copy gene and exists in a large number of copies in the Anaplasma phagocytophilum genome, thus having the effect of detecting Anaplasma phagocytophilum infection at high sensitivity using only a small amount of DNA compared to conventional diagnostic marker genes. In addition, the primer set or probe for detecting and amplifying P44 is capable of providing rapid and easy detection of anaplasmosis with high specificity and sensitivity, making it appropriate for early detection of anaplasmosis.
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