公开(公告)号：US20150297673A1

公开(公告)日：2015-10-22

申请号：US14789041

申请日：2015-07-01

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

Inventor： Yoon Kyung PARK ,  Jong Kuk LEE

IPC: A61K38/10 ,  C07K7/08

CPC classification number: A61K38/10 ,  C07K7/08 ,  C07K14/205 ,  Y02A50/473

Abstract: The present invention relates to a novel antibiotic peptide originated from the ribosomal protein L1 of Helicobacter pylori and a use of the same. Particularly, the novel peptide represented by SEQ. ID. NO: 4 was synthesized by replacing phenylalanine, the 12th amino acid of the peptide composed of the amino acid sequence represented by SEQ. ID. NO: 3, with proline. The present inventors confirmed that the novel peptide had a significant antibacterial activity but had no cytotoxicity. In addition, the inventors confirmed that the peptide of the invention had in vivo anti-inflammatory effect, so that the novel peptide can be used as an active ingredient of a natural antibacterial agent.

Abstract translation: 本发明涉及一种起源于幽门螺杆菌的核糖体蛋白L1的新型抗生素肽及其应用。 特别地，SEQ ID NO： ID。 通过将由SEQ ID NO：1表示的氨基酸序列构成的肽的第12位氨基酸替代为苯丙氨酸来合成NO：4。 ID。 NO：3，用脯氨酸。 本发明人证实，该新型肽具有显着的抗菌活性，但没有细胞毒性。 此外，本发明人确认本发明的肽具有体内抗炎作用，因此可以将新型肽用作天然抗菌剂的有效成分。