公开(公告)号：US10508200B2

公开(公告)日：2019-12-17

申请号：US15772992

申请日：2016-11-04

申请人： INGELL TECHNOLOGIES HOLDING B.V.

发明人： Ronald Meijboom ,  Paul Marcel Van Midwoud ,  Maarten Van Dijk ,  Theodorus Adrianus Cornelius Flipsen ,  Esther De Boef

IPC分类号： C08L71/02 ,  A61L27/18 ,  A61L27/54 ,  A61K9/00 ,  A61K47/10 ,  A61K47/34 ,  A61K9/107 ,  C08G63/664 ,  A61L27/58

摘要： A composition including a) 55-98.9 wt % of at least one type of triblock copolymer (A) of formula (1) R—B-A-B—R  (1) b) 0.1-15 wt % of at least one surfactant (B) and c) 1-30 wt % of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers having at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0° C. to 37° C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt % of the entire composition, preferably at least 90 wt %; to the use of the composition and to pharmaceutical compositions having said composition and an active pharmaceutical ingredient.