公开(公告)号：US20200023071A1

公开(公告)日：2020-01-23

申请号：US16483758

申请日：2018-02-05

Applicant: INNATE PHARMA

Inventor： MATHIEU BLERY ,  DELPHINE BREGEON ,  LAURENT GAUTHIER ,  FLORENCE LHOSPICE ,  LAURENT POUYET

IPC: A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  A61K31/551 ,  A61K38/07

Abstract: The present invention provides antigen-binding proteins capable of binding to human MICA polypeptides, conjugated to cytotoxic agents. Said conjugates have increased activity in the treatment of disorders characterized by MICA-expressing cells, particularly tumor cells.