公开(公告)号：US20220213202A1

公开(公告)日：2022-07-07

申请号：US17566142

申请日：2021-12-30

Applicant: INNATE PHARMA ,  SANOFI

Inventor： Céline AMARA ,  Céline NICOLAZZI ,  Marielle CHIRON ,  Francis DUFFIEUX ,  Jochen BENINGA ,  Angela VIRONE-ODDOS ,  Laurent GAUTHIER ,  Ariane THIELENS ,  Benjamin ROSSI

IPC: C07K16/28 ,  A61P35/02

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human CD123 and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof to a human Fc-γ receptor.
The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including Acute Myeloid Leukemia (AML) and myelodysplastic syndromes (MDS).

公开(公告)号：US20240034816A1

公开(公告)日：2024-02-01

申请号：US18469947

申请日：2023-09-19

Applicant: SANOFI ,  INNATE PHARMA

Inventor： Nicolas GOURDIN ,  Laurent GAUTHIER ,  Alexandre TANG ,  Marielle CHIRON ,  Angela VIRONE-ODDOS ,  Alessandro MASIERO ,  Jochen BENINGA ,  Ingo FOCKEN ,  Sambasiva RAO ,  Yanfeng ZHOU ,  Leila SEVIGNY

IPC: C07K16/46 ,  C12N15/63 ,  A61P35/00

CPC classification number: C07K16/468 ,  C12N15/63 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/41 ,  C07K2317/14 ,  C07K2317/31

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor.
The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

公开(公告)号：US20160030438A1

公开(公告)日：2016-02-04

申请号：US14775370

申请日：2014-03-14

Applicant: SANOFI

Inventor： Hélène BONNEVAUX ,  Carlos GARCIA-ECHEVERRIA ,  Angela VIRONE-ODDOS

IPC: A61K31/5377 ,  G01N33/50 ,  A61K31/437

CPC classification number: A61K31/5377 ,  A61K31/437 ,  A61K31/5375 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/57496 ,  A61K2300/00

Abstract: The present invention concerns a combination of a PI3Kβ inhibitor with a RAF inhibitor for its use for the treatment of a patient resistant to at least one RAF inhibitor, a kit comprising the same, its pharmaceutical uses thereof and a method of monitoring the efficiency of said combination when administered to a patient.

Abstract translation: 本发明涉及PI3K和bgr的组合; 抑制剂，其用于治疗对至少一种RAF抑制剂有抗性的患者的RAF抑制剂，包含该RAF抑制剂的试剂盒，其药物用途以及当向患者施用时监测所述组合的效率的方法。

公开(公告)号：US20250042993A1

公开(公告)日：2025-02-06

申请号：US18790955

申请日：2024-07-31

Applicant: SANOFI

Inventor： Elisabeth REMY ,  Klervi DESRUMEAUX ,  Helene BONNEVAUX ,  Marco MELONI ,  Angela VIRONE-ODDOS ,  Marielle Chiron Blondel

IPC: C07K16/28 ,  A61P35/00

Abstract: The present disclosure provides antigen-binding proteins specifically binding GPRC5D, as well as respective antibodies in enhanced ADCC formats, and methods of using them to treat cancers such as multiple myeloma.

公开(公告)号：US20160030440A1

公开(公告)日：2016-02-04

申请号：US14781890

申请日：2014-04-03

Applicant: SANOFI

Inventor： Héléne BONNEVAUX ,  Carlos GARCIA-ECHEVERRIA ,  Angela VIRONE-ODDOS

IPC: A61K31/5377 ,  A61K31/4439

CPC classification number: A61K31/5377 ,  A61K31/4439 ,  A61K31/513 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention concerns a combination of a PI3Kβ selective inhibitor with a PI3Kα selective inhibitor for use in the treatment of cancer.

Abstract translation: 本发明涉及PI3K和bgr的组合; 选择性抑制剂与用于治疗癌症的PI3Kα选择性抑制剂。

公开(公告)号：US20250064935A1

公开(公告)日：2025-02-27

申请号：US18771699

申请日：2024-07-12

Applicant: SANOFI

Inventor： Giovanni ABBADESSA ,  Marielle CHIRON ,  Alain FOURNIER ,  Paula FRAENKEL ,  Angela VIRONE-ODDOS

IPC: A61K39/00 ,  C07K16/28 ,  C12N5/0783

Abstract: Provided herein are compositions and methods of treating or preventing a hematological disease or disorder in a subject in need thereof, comprising expanded NK cells and a binding protein comprising a first antigen binding domain with binding specificity to CD123 and a second antigen binding domain with binding specificity to NKp46.

公开(公告)号：US20230416395A1

公开(公告)日：2023-12-28

申请号：US18300834

申请日：2023-04-14

Applicant: SANOFI

Inventor： Marielle CHIRON BLONDEL ,  Cendrine LEMOINE ,  Angela VIRONE-ODDOS ,  Béatrice CAMERON ,  Jacques DUMAS ,  Alain FOURNIER ,  Jonathan KINGSBURY ,  Brian MURRAY ,  Nathan OSTBERG ,  Sanket PATKE ,  Zichuan ZHANG

IPC: C07K16/28 ,  A61K47/26 ,  A61K9/19 ,  A61K47/18

CPC classification number: C07K16/2896 ,  A61K47/26 ,  A61K9/19 ,  A61K47/183 ,  C07K2317/92 ,  C07K2317/732 ,  C07K2317/72 ,  C07K2317/94

Abstract: Provided herein are antibodies that specifically bind human CD38, formulations and unit dosage forms comprising the antibodies, methods of preparing the antibodies and methods of using the antibodies.