公开(公告)号：US20160138104A1

公开(公告)日：2016-05-19

申请号：US14898591

申请日：2014-06-18

申请人： UNIVERSITE DE MONTPELLIER ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER ,  INSTITUT REGIONAL DU CANCER DE MONTPELLIER

发明人： Samir HAMAMAH ,  Safia EL MESSAOUDI ,  Alain THIERRY ,  Said ASSOU

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nude is acid extraction.

摘要翻译： 本发明一般涉及生殖医学领域。 更具体地，本发明涉及用于通过确定无细胞核酸的水平和/或确定至少一种特定核酸的存在和/或表达水平来确定胚胎质量的体外非侵入性方法和试剂盒 裸体中的序列是酸提取。

公开(公告)号：US20170240975A1

公开(公告)日：2017-08-24

申请号：US15518392

申请日：2015-10-20

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  INSTITUT REGIONAL DU CANCER DE MONTPELLIER ,  UNIVERSITE DE MONTPELLIER

发明人： Alain THIERRY ,  Safia EL MESSAOUDI

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention relates to methods for screening a subject for a cancer. In particular, the present invention relates to a method (A) for screening a subject for a cancer comprising the steps of i) extracting the cell free nucleic acids from a sample obtained from the subject, ii) determining the total concentration of mitochondrial cell free nucleic acids, ii) determining the total concentration of nuclear cell free nucleic acids iv) calculating the ratio of the level determined at step ii) to the concentration determined at step iii), v) comparing ratio determined at step iv) with a predetermined corresponding reference value and vi) concluding that the subject suffers from a cancer when the ratio determined at step iv) is lower than the predetermined corresponding reference value or concluding that the subject does not suffer from a cancer when the ratio determined at step iv) is higher than the predetermined corresponding reference value.

公开(公告)号：US20240124940A1

公开(公告)日：2024-04-18

申请号：US18481306

申请日：2023-10-05

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  INSTITUT REGIONAL DU CANCER DE MONTPELLIER ,  UNIVERSITE DE MONTPELLIER

发明人： Alain THIERRY ,  Safia EL MESSAOUDI

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Methods for screening a subject for a cancer are provided. In particular, the methods include i) extracting the cell free nucleic acids from a sample obtained from the subject, ii) determining the total concentration of mitochondrial cell free nucleic acids, ii) determining the total concentration of nuclear cell free nucleic acids iv) calculating the ratio of the level determined at step ii) to the concentration determined at step iii), v) comparing ratio determined at step iv) with a predetermined corresponding reference value and vi) concluding that the subject suffers from a cancer when the ratio determined at step iv) is lower than the predetermined corresponding reference value or concluding that the subject does not suffer from a cancer when the ratio determined at step iv) is higher than the predetermined corresponding reference value.

公开(公告)号：US20220106643A1

公开(公告)日：2022-04-07

申请号：US17472848

申请日：2021-09-13

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE MONTPELLIER ,  CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER ,  INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER

发明人： Samir HAMAMAH ,  Safia EL MESSAOUDI ,  Alain THIERRY ,  Said ASSOU

IPC分类号： C12Q1/6883

摘要： The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nucleic acid extraction.

公开(公告)号：US20190002985A1

公开(公告)日：2019-01-03

申请号：US16135293

申请日：2018-09-19

申请人： INSERM (Institut National De La Sante Et De La Recherche Medicale) ,  UNIVERSITE DE MONTPELLIER ,  CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER ,  INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER

发明人： Samir HAMAMAH ,  Safia EL MESSAOUDI ,  Alain THIERRY ,  Said ASSOU

IPC分类号： C12Q1/6883

摘要： The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nucleic acid extraction.