专利检索 ap:("INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)" OR "INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER" OR "UNIVERSITÉ DE MONTPELLIER") AND inv:"Romain LANOTTE" 第 1 页

1.

发明申请
ANTIBODIES HAVING SPECIFICITY TO HER4 AND USES THEREOF 有权

公开(公告)号：US20230040928A1

公开(公告)日：2023-02-09

申请号：US17783182

申请日：2020-12-08

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER , UNIVERSITÉ DE MONTPELLIER

发明人： Andre PELEGRIN , Pierre MARTINEAU , Thierry CHARDES , Romain LANOTTE

IPC分类号： C07K16/32 , A61K47/68 , A61P35/00 , A61P15/00

摘要： The present invention relates to antibodies having specificity to HER4 and uses thereof, which are able to induce biased 4ICD routing/signaling. The inventors have isolated by antibody phage display three fully human anti-HER4 single-chain variable antibody fragment (scFv), selected on human HER4 extracellular domain, referred as C6 mAb, D5 mAb and F4 mAb and one fully human anti-HER4 scFv named H2 mAb, selected on NRG 1β1-stimulated EGFR/HER4 JMaCYT1-transfected NIH3T3 cells. In particular, the present invention relates to an isolated anti-HER4 antibody, wherein said antibody binds to an epitope of the HER4 protein.