专利检索 ap:("INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)" OR "UNIVERSITÉ DE NANTES") AND inv:"Sandrine BEZIE" 第 1 页

1.

发明申请
AN ISOLATED INTERLEUKIN-34 POLYPEPTIDE FOR USE IN PREVENTING TRANSPLANT REJECTION AND TREATING AUTOIMMUNE DISEASES 审中-公开

公开(公告)号：US20170202921A1

公开(公告)日：2017-07-20

申请号：US15326515

申请日：2015-07-17

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE NANTES

发明人： Carole GUILLONNEAU , Ignacio ANEGON , Sandrine BEZIE

IPC分类号： A61K38/20 , A61K31/436 , A61K45/06

CPC分类号： A61K38/20 , A61K31/436 , A61K45/06 , G01N33/564 , G01N33/6893 , G01N2333/54 , G01N2800/245 , G01N2800/50 , A61K2300/00

摘要： The invention relates to an isolated interleukin-34 (IL-34) polypeptide for use in preventing or treating graft rejection, autoimmune disease, unwanted immune response against therapeutic proteins and allergy. The invention also provides an in vitro method for determining whether a patient is at risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies, comprising a step of determining the expression level of IL-34 in a biological sample obtained from said patient, wherein the presence of IL-34 is indicative of a reduced risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies.