专利检索 ap:("INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)" OR "UNIVERSITE D'AIX MARSEILLE") AND inv:"Nadine Bruneau" 第 1 页

1.

发明授权
Compounds for treating CMV related diseases 有权

公开(公告)号：US11690856B2

公开(公告)日：2023-07-04

申请号：US16758292

申请日：2018-10-22

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE D'AIX MARSEILLE

发明人： Pierre Szepetowski , Robin Cloarec , Sylvian Bauer , Nadine Bruneau

IPC分类号： A61K31/65 , A61P25/28 , A61K31/663

CPC分类号： A61K31/65 , A61K31/663 , A61P25/28

摘要： The present invention relates the field of CMV and CMV related diseases. Using a powerful rat model of CMV infection of the embryonic brain, the inventors have looked for the existence of postnatal neurological and neurosensory manifestations, and have tested whether the early pharmacological targeting of microglia during pregnancy impacts on postnatal phenotypes. Particularly, the inventors tested the clodronate and the doxycycline and showed that these compounds improve the postnatal outcome of the baby. Thus, the invention relates to a compound which modifies the microglia for use in the treatment of CMV related diseases in a subject in need thereof.