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公开(公告)号:US10151745B2
公开(公告)日:2018-12-11
申请号:US14646486
申请日:2013-11-21
申请人: INSERM (Institut National De La Santé Et De La Recherche Médicale) , Centre National de la Recherche Scientifique (CNRS) , Assistance Publique—Hopitaux de Paris , Université Paris Descartes , Imagine Institut des Maladies Genetiques Necker Enfants Malades
IPC分类号: G01N33/50 , G01N33/569 , G01N33/68
摘要: The present invention relates to a method for determining whether a candidate human transplant donor is at risk of inducing acute graft versus host disease (aGVHD) in a human transplant recipient, which may in turn allow the selection of a donor exhibiting no risk for the recipient. The present invention also relates to a method for adjusting the immunosuppressive treatment administered to a human transplanted recipient following its graft transplantation after having performing the method for determining risk of the invention. The methods comprise expanding the candidate donor's iNKT cells (invariant NKT cells) and determining the presence or absence of expansion of the CD4(−) iNKT cell sub-population. In particular, CD3+CD4− TCRV[alpha]24V[beta]11 cells are determined. Kits are disclosed.