专利检索 ap:("INSERM (Institut National de la Sante et de la Recherche Medicale)" OR "Universite Paul Sabatier Toulouse III" OR "Centre National de la Recherche Scientifique (CNRS)" OR "Centre Hospitalier Universitaire de Toulouse" OR "Institut Claudius Regaud") AND inv:"Mary POUPOT" 第 1 页

1.

发明申请
ANTIBODIES TARGETING TUMOR ASSOCIATED MACROPHAGES AND USES THEREOF 有权

公开(公告)号：US20210292408A1

公开(公告)日：2021-09-23

申请号：US16319956

申请日：2017-07-28

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS) , Centre Hospitalier Universitaire de Toulouse , Institut Claudius Regaud

发明人： Mary POUPOT , Loïc YSEBAERT , Marie TOSOLINI , Jean-Jacques FOURNIE , Pierre BROUSSET , Philippe ROCHAIX

IPC分类号： C07K16/28 , G01N33/574

摘要： The present invention relates to antibodies targeting Tumor Associated Macrophages (TAMs) and uses thereof. The inventors investigated specific marker exposed on the surface of the macrophages associated to tumor in order to detect and target TAMs. They showed that sideroflexin 3, which is absent in normal macrophage, is expressed by tumor associated macrophages. The inventors further demonstrated that using antibody directed to sideroflexin 3, they depleted TAMs in PBMC sample obtained from LCC patient, and strongly reduced leukemic B cells number.

2.

发明申请
METHODS OF TREATEMENT OF CANCER DISEASE BY TARGETTING TUMOR ASSOCIATED MACROPHAGE 审中-公开

公开(公告)号：US20190271702A1

公开(公告)日：2019-09-05

申请号：US16319948

申请日：2017-07-28

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)

发明人： Mary POUPOT , Loïc YSEBAERT , Marie TOSOLINI , Jean-Jacques FOURNIE

IPC分类号： G01N33/574 , A61P35/00 , A61P35/02 , C07K16/18 , C12N15/113

摘要： The present invention relates to methods of treatment of cancer by targeting tumor associated macrophages. The inventors investigated specific marker exposed on the surface of the macrophage associated tumor in order to detect and target TAMs. They showed that sideroflexin 3, which is absent in normal macrophage, is expressed by tumors associated macrophage. The relates to a method for identifying tumor-associated macrophage (TAM) in a sample comprising the steps of i) detecting the cell surface expression of CD163, CD68, and SFXN3 markers on the cell population contained in the sample and ii) concluding that the cells expressing CD163, CD68, and SFXN3 markers are the TAMs.