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公开(公告)号:US11229356B2
公开(公告)日:2022-01-25
申请号:US16499386
申请日:2018-03-29
申请人: INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人: Pierre Pouget , Pierre Daye , Jean Lorenceau
摘要: Evaluation of the perception of colors by mammals with a view to obtaining a characteristic biomarker of each tested subject takes advantage of the slow pupillary oscillatory response to generate an objective neurological signature of this perception of colors. A method based on pupil frequency tagging is used at a tagging frequency Ftag adapted to the pupil response speed. A dynamic two-color stimulus is displayed, this stimulus comprising a two-color pattern the colors of which are inverted at the frequency Ftag, one of the colors gradually varying in a range of possible values. From the pupillary response, a signal representative of the oscillation power of the pupil is generated. The minimum of this signal corresponds to the relative iso-luminance of the tested pair of colors.
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2.
公开(公告)号:US20200037870A1
公开(公告)日:2020-02-06
申请号:US16499782
申请日:2018-03-29
申请人: INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人: Pierre Pouget , Alexis Genin
摘要: A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.
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公开(公告)号:US11464407B2
公开(公告)日:2022-10-11
申请号:US16499782
申请日:2018-03-29
申请人: INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人: Pierre Pouget , Alexis Genin
摘要: A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.
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