专利检索 ap:("INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES") AND inv:"Shuang WANG" 第 1 页

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发明申请
EXOSOME-BASED ANTITUMOR VACCINE 有权

公开(公告)号：US20210324342A1

公开(公告)日：2021-10-21

申请号：US17269897

申请日：2019-08-16

申请人： INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES

发明人： Guanghui MA , Wei WEI , Shuang WANG , Shuang QING , Jianghua WANG

IPC分类号： C12N5/16 , A61K39/00 , C07K16/28 , A61P35/00

摘要： Provided is an exosome, which is secreted by a hybrid cell formed by antigen-presenting cells phagocytosing the cell nuclei of tumor cells. Using the strategy of macrophages phagocytosing the cell nuclei of tumor cells achieves endogenous expression of tumor antigens on macrophages, and the exosome prepared has good capabilities of targeting to lymph nodes and tumors dually.