公开(公告)号：US20210317060A1

公开(公告)日：2021-10-14

申请号：US17045477

申请日：2019-04-06

Applicant: INSTYTUT FARMACEUTYCZNY

Inventor： Katarzyna SIDORYK ,  Marek NAPIORKOWSKI ,  Agnieszka BURZYNSKA-PRAJZNER ,  Marcin CYBULSKI ,  Marek KUBISZEWSKI ,  Kamil JATCZAK ,  Lukasz JEDYNAK ,  Jerzy WINIARSKI ,  Dorota PIETRZKOWSKA ,  Konrad ZIELINSKI

IPC: C07C46/04

Abstract: Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.

公开(公告)号：US20130190538A1

公开(公告)日：2013-07-25

申请号：US13733855

申请日：2013-01-03

Applicant: INSTYTUT FARMACEUTYCZNY ,  WARSZAWSKI UNIWERSYTET MEDYCZNY

Inventor： Mariusz GRUZA ,  Oliwia ZEGROCKA-STENDEL ,  Tomasz GILLER ,  Grzegorz GRYNKIEWICZ ,  Marta LASZCZ ,  Kamil JATCZAK

IPC: C07C29/09 ,  C07C35/44

CPC classification number: C07C29/095 ,  C07C29/74 ,  C07C29/78 ,  C07C31/278 ,  C07C35/44 ,  C07J63/00 ,  C07J63/008

Abstract: A process for the preparation of protoescigenin by hydrolysis of escin isolated from Aesculus hippocastanum. The process includes the following steps: a two-step hydrolysis first under acidic and then basic conditions, enrichment of the crude mixture of sapogenins with protoescigenin, an isolation of the mixture of sapogenins in a solid form, and a purification of the obtained solid and isolation of high purity protoescigenin. The invention also relates to protoescigenin monohydrate in a crystalline form and the preparation thereof. Protoescigenin is a polyhydroxy aglycone, which can be used as a synthon in the chemical modifications of naturally occurring saponins.

Abstract translation: 一种通过水解从七叶树七叶皂苷中分离的七叶皂苷制备原丝酵母素的方法。 该方法包括以下步骤：首先在酸性和碱性条件下进行两步水解，将粗皂苷元粗制混合物与原丝酵母素进行富集，分离固体形式的皂角蛋白的混合物，以及所得固体和 隔离高纯度原丝酵母。 本发明还涉及结晶形式的原生精皮质素一水合物及其制备方法。 原花青素是多羟基苷元，可用作天然皂苷的化学修饰中的合成子。