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公开(公告)号:US20200247812A1
公开(公告)日:2020-08-06
申请号:US16635029
申请日:2019-07-09
发明人: Sarvajit Chakravarty , Dhananjay Pendharkar , Brahmam Pujala , Anil Kumar Agarwal , Varun Kumar , Satish Kumar Arya
IPC分类号: C07D487/04 , C07D401/12 , C07D471/04 , C07D519/00 , C07D401/14 , C07D413/14 , C07D417/14 , C07D409/14 , C07D407/14 , C07D498/04 , C07D513/04 , A61P35/00
摘要: The present invention discloses compounds useful in treatment of conditions associated with excessive activity of transforming growth factor beta (TGF-β), particularly type I or activin-like kinase 5 (ALK 5). Specifically, the present invention discloses compound of formula (I) which exhibit inhibitory activity against ALK 5. Method of treating conditions associated with excessive activity (ALK 5) with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
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公开(公告)号:US20220135598A1
公开(公告)日:2022-05-05
申请号:US17515758
申请日:2021-11-01
发明人: Brahmam Pujala , Amantullah Ansari , Shreya Sapra , Pradeep S. Jadhavar , Dhananjay Pendharkar , Sreekanth A. Ramachandran , Uzma Saeed , Abhinandan Danodia , Farha Khan , Sagar Patni , Sanjeev Soni , Ashu Gupta , Sarvajit Chakravarty , Balaji Dashrath Sathe
IPC分类号: C07F5/02 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/056 , C07F9/6558 , C07D401/14 , C07D403/14
摘要: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
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