公开(公告)号：US09624230B2

公开(公告)日：2017-04-18

申请号：US14671531

申请日：2015-03-27

Applicant: INTRA-CELLULAR THERAPIES, INC.

Inventor： Peng Li ,  Haiyan Wu

IPC: A61K31/519 ,  C07D487/14

CPC classification number: C07D487/14

Abstract: The invention provides novel 7,8-dihydro-imidazo[1,2-α]pyrazolo[4,3-e]pyrimidin-4-one compounds and 7,8,9-trihydro-[1H or 2/f]-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one compounds, substituted at the 1 or 2 position with C2-g allcyl, C3-9 cycloalkyl, heteroarylalkyl, or substituted arylalkyl, in free, salt or prodrug form, processes for their production, their use as pharmaceuticals, particularly as PDE1 inhibitors, and pharmaceutical compositions comprising them.