公开(公告)号：US3865814A

公开(公告)日：1975-02-11

申请号：US38246173

申请日：1973-07-25

Applicant: INVENTA AG

Inventor： LUSSI HEINZ ,  BERTHER CLAU ,  STUDINKA JOSEF

IPC: C07D223/10 ,  C07D207/26 ,  C07D207/267 ,  C07D211/76 ,  C07D225/02 ,  C07D227/087 ,  C07D41/06

CPC classification number: C07D207/267 ,  C07D227/087

Abstract: A process for the preparation of N-substituted lactams of the formula

WHEREIN A is a substituted or unsubstituted aliphatic hydrocarbon chain having 3 to 11 carbon atoms, said substituents comprising one or more alkyl groups each having 1 to 4 carbon atoms; and R is hydrogen or a hydrocarbon radical having 1 to 17 carbon atoms, comprising reacting at least one starting lactam of the formula

WITH AN ORGANIC HALOGEN COMPOUND OF THE FORMULA X - CH2-R wherein X is chlorine, bromine or iodine, in the presence of an alkali metal hydroxide in solid form or in at least 50% aqueous solution at a reaction temperature of from 20*C to 120*C.

Abstract translation: 制备式（III）的N-取代的内酰胺的方法是取代或未取代的具有3至11个碳原子的脂族烃链，所述取代基包括一个或多个各自具有1至4个碳原子的烷基; 并且R是氢或具有1至17个碳原子的烃基，其包括使式的至少一种起始内酰胺与式X-CH 2 -R的有机卤素化合物反应，其中X为氯，溴或碘， 的固体形式的碱金属氢氧化物或在20℃至120℃的反应温度下的至少50％的水溶液中。