公开(公告)号：US20200230117A1

公开(公告)日：2020-07-23

申请号：US16088873

申请日：2017-04-24

申请人： Phillip M. COWLEY ,  Meredeth Ann MCGOWAN ,  Thomas J. BROWN ,  WISE Alan ,  Hua ZHOU ,  Yongxin HAN ,  Kun LIU ,  Qinglin PU ,  Hongjun ZHANG ,  IOMet Pharma Ltd.

发明人： Phillip M. Cowley ,  Meredeth Ann McGowan ,  Thomas J. Brown ,  Yongxin Han ,  Kun Liu ,  Qinglin Pu ,  Alan Wise ,  Hongjun Zhang ,  Hua Zhou

IPC分类号： A61K31/438 ,  C07D519/00

摘要： Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.

公开(公告)号：US11096930B2

公开(公告)日：2021-08-24

申请号：US16088873

申请日：2017-04-24

申请人： IOMet Pharma Ltd.

发明人： Phillip M. Cowley ,  Meredeth Ann McGowan ,  Thomas J. Brown ,  Yongxin Han ,  Kun Liu ,  Qinglin Pu ,  Alan Wise ,  Hongjun Zhang ,  Hua Zhou

IPC分类号： C07D519/00 ,  A61K31/438

摘要： Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.