公开(公告)号：US09757047B2

公开(公告)日：2017-09-12

申请号：US13815815

申请日：2013-03-14

申请人： Isis Innovation Ltd.

发明人： Michael Chappell ,  Mark Woolrich ,  Thomas Okell

IPC分类号： G01V3/00 ,  A61B5/026 ,  G01R33/563

CPC分类号： A61B5/0263 ,  G01R33/56333 ,  G01R33/56366 ,  G06F19/00

摘要： Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis.

公开(公告)号：US20130249547A1

公开(公告)日：2013-09-26

申请号：US13815815

申请日：2013-03-14

申请人： ISIS INNOVATION LTD.

发明人： Michael Chappell ,  Mark Woolrich ,  Thomas Okell

IPC分类号： A61B5/026

CPC分类号： A61B5/0263 ,  G01R33/56333 ,  G01R33/56366 ,  G06F19/00

摘要： Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis.

摘要翻译： 动脉自旋标记（ASL）MRI提供了非侵入性手段，用于在动态血管造影成像中产生血源性对比。 通过ASL过程的空间调制，可以通过一系列测量来独特地标记单个动脉，从而允许每个动脉在所得到的图像中单独识别。 这种分离需要适当的分析，以前提出了一个总体框架。 在这里，使用血管编码的动脉自旋标记（VE-ASL）修改用于快速分析血流非侵入性成像的一般框架。 这具体解决了分析的计算速度和处理真实患者数据所需的鲁棒性的问题。 该修改应用各种方法来估计一个或多个参数，这些参数改变了血管（例如动脉）被编码以提供快速分析的方式。