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    METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1-ANTITRYPSIN EXPRESSION
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1-ANTITRYPSIN EXPRESSION 有权
    调节ALPHA-1抗体表达的方法和组合物

    公开(公告)号：US20150087691A1

    公开(公告)日：2015-03-26

    申请号：US14386246

    申请日：2013-03-19

    申请人： Isis Pharmaceuticals, Inc.

    发明人： Brett P. Monia ,  Michael L. McCaleb ,  Susan M. Freier ,  Shuling Guo

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  C07K14/8125 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346

    摘要： Disclosed herein are methods for decreasing AIAT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping progression of fibrosis. Disclosed herein are methods for decreasing AIAT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping progression of liver disease, such as, AIATD associated liver disease, and pulmonary disease, such as, AIATD associated pulmonary disease in an individual in need thereof. Methods for inhibiting AIAT mRNA and protein expression can also be used as a prophylactic treatment to prevent individuals at risk for developing a liver disease, such as, AIATD associated liver disease and pulmonary disease, such as, AIATD associated pulmonary disease.

    摘要翻译： 本文公开了减少AIAT mRNA和蛋白质表达并治疗，改善，预防，减缓进展或停止纤维化进展的方法。 本文公开了用于降低AIAT mRNA和蛋白质表达以及治疗，改善，预防，减缓进展或停止肝脏疾病如AIATD相关肝病和肺部疾病（例如个体中的AIATD相关肺疾病）的进展的方法 需要它。 用于抑制AIAT mRNA和蛋白质表达的方法也可用作预防性治疗，以预防患有发生肝病，例如AIATD相关肝病和肺部疾病如AIATD相关肺疾病的风险的个体。