公开(公告)号：US20220265658A1

公开(公告)日：2022-08-25

申请号：US17625522

申请日：2020-07-08

申请人： Idorsia Pharmaceuticals Ltd.

发明人： Michael AMBUEHL ,  Elvire FOURNIER ,  Amandine FRAICHARD ,  Sylvie FROIDEVAUX ,  Oliver GEISELER ,  Charlyse HERRMANN ,  Francis HUBLER ,  Mark MURPHY ,  Dorte RENNEBERG ,  Simon STAMM ,  Markus VON RAUMER

IPC分类号： A61K31/519 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/44 ,  A61K9/107 ,  A61K9/48

摘要： The invention relates to pharmaceutical compositions, which are self-emulsifying, self-microemulsifying, or self-nanoemulsifying in aqueous medium, comprising the compound: 2-(2,2-Difluoro-propyl)-5-[1-(2-fluoro-6-methyl-phenyl)-piperidin-4-yl]-7-(2-trifluoromethyl-benzyl)-2,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-6-one and a mixture of excipients comprising one or more lipophilic excipient(s); one or more hydrophilic surfactant(s); and optionally one or more hydrophilic co-solvent(s). The invention further relates to a crystalline form of said compound, and its use for the preparation of the present compositions. The invention further relates to pharmaceutical uses of the compositions for the prevention/prophylaxis or treatment of diseases and disorders related to pathogenic events associated with elevated levels of C5a and/or with C5aR activation.

公开(公告)号：US20230255987A1

公开(公告)日：2023-08-17

申请号：US18016299

申请日：2021-07-14

申请人： Idorsia Pharmaceuticals Ltd

发明人： Stephan BUCHMANN ,  Amandine FRAICHARD ,  Charlyse HERRMANN ,  Céline LIENHART ,  Markus VON RAUMER ,  Tobias WERK

IPC分类号： A61K31/675 ,  A61K9/08 ,  A61K47/18 ,  A61K47/24 ,  A61K47/02

CPC分类号： A61K31/675 ,  A61K9/08 ,  A61K47/183 ,  A61K47/24 ,  A61K47/18 ,  A61K47/02

摘要： The present invention relates to an aqueous pharmaceutical composition comprising the P2Y12 receptor antagonist 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester and a pharmaceutically acceptable buffer and its use as a medicament by parenteral administration.