公开(公告)号：US20190047996A1

公开(公告)日：2019-02-14

申请号：US15759710

申请日：2016-09-14

申请人： IDORSIA PHARMACEUTICALS LTD.

发明人： Hamed AISSAOUI ,  Christoph BOSS ,  Patrick BOUIS ,  Julien HAZEMANN ,  Romain SIEGRIST ,  Markus VON RAUMER

IPC分类号： C07D471/04 ,  A61P37/08 ,  A61P37/02

CPC分类号： C07D471/04 ,  A61P37/02 ,  A61P37/08 ,  C07B2200/13

摘要： The invention relates to a crystalline form of (S)-2-(8-((5-chloropyrimidin-2-yl)(methyl)amino)-2-fluoro-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-5-yl)acetic acid, processes for the preparation thereof, pharmaceutical compositions comprising said crystalline forms, pharmaceutical compositions prepared from such crystalline forms, and their use as a medicament, especially as CRTH2 receptor modulators.

公开(公告)号：US20180105496A1

公开(公告)日：2018-04-19

申请号：US15847611

申请日：2017-12-19

申请人： IDORSIA PHARMACEUTICALS LTD

发明人： Romain SIEGRIST ,  Bibia HEIDMANN ,  Simon STAMM ,  John GATFIELD ,  Olivier BEZENCON

IPC分类号： C07D231/40 ,  C07D403/06 ,  C07D471/04 ,  C07D413/12 ,  C07D405/12 ,  C07D403/12 ,  C07D401/06 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12

CPC分类号： C07D231/40 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04

摘要： The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

公开(公告)号：US20230303486A1

公开(公告)日：2023-09-28

申请号：US18003226

申请日：2021-06-24

申请人： Idorsia Pharmaceuticals Ltd

发明人： Olivier BEZENCON ,  Caroline DEYMIER ,  Jens-Uwe PETERS ,  Romain SIEGRIST ,  Jean-Philippe SURIVET

IPC分类号： C07C275/26 ,  C07D213/40 ,  C07D239/26 ,  A61P25/08

CPC分类号： C07C275/26 ,  A61P25/08 ,  C07D213/40 ,  C07D239/26 ,  C07C2601/04

摘要： The invention relates to compounds of Formula (I)





wherein X1, X2, X3, L, RX4, R1, R2A, R2B, R3, R4, R5, and R6 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.

公开(公告)号：US20230136562A1

公开(公告)日：2023-05-04

申请号：US17997483

申请日：2021-04-27

申请人： Idorsia Pharmaceuticals Ltd

发明人： Olivier BEZENCON ,  Caroline DEYMIER ,  Jens-Uwe PETERS ,  Romain SIEGRIST ,  Jean-Philippe SURIVET

IPC分类号： C07C275/26 ,  C07D213/16 ,  C07D217/26 ,  C07D239/26 ,  C07D257/04 ,  C07D255/02 ,  C07C317/28

摘要： The invention relates to compounds of Formula (I) wherein X1, X2, X3, Y, R1, R2A, R2B, R3, and R4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.