专利检索 ap:("Ignacio LIZASOAIN HERNANDEZ" OR "Victor Manuel GONZALEZ MUÑOZ" OR "Geronimo FERNANDEZ GOMEZ -CHACON" OR "Maria Angeles MORO SANCHEZ" OR "Maria Elena MARTIN PALMA" OR "Ana MORAGA YEBENES") AND inv:"Ana MORAGA YEBENES" 第 1 页

1.

发明公开
Aptamers Specific for TLR-4 and Uses Thereof 审中-公开

公开(公告)号：US20230279402A1

公开(公告)日：2023-09-07

申请号：US18156936

申请日：2023-01-19

申请人： Ignacio LIZASOAIN HERNANDEZ , Victor Manuel GONZALEZ MUÑOZ , Geronimo FERNANDEZ GOMEZ -CHACON , Maria Angeles MORO SANCHEZ , Maria Elena MARTIN PALMA , Ana MORAGA YEBENES

发明人： Ignacio LIZASOAIN HERNANDEZ , Victor Manuel GONZALEZ MUÑOZ , Geronimo FERNANDEZ GOMEZ -CHACON , Maria Angeles MORO SANCHEZ , Maria Elena MARTIN PALMA , Ana MORAGA YEBENES

IPC分类号： C12N15/115 , A61K31/7088 , G01N33/566

CPC分类号： C12N15/115 , A61K31/7088 , G01N33/566 , C12N2310/16 , C12N2310/53 , G01N2333/70596

摘要： The invention relates to a nucleic acid aptamer with the capability of binding specifically to a and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and to uses and methods for inhibiting TLR-4. Finally, the invention also relates to an aptamer for use in manufacturing a drug for the treatment of a pathology characterized by an increase in expression of TLR4 and/or an increase in activation of TLR-4.