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    Method and apparatus for synchronizing neural stimulation to cardiac cycles
    3.
    发明授权
    Method and apparatus for synchronizing neural stimulation to cardiac cycles 有权
    用于将神经刺激与心脏周期同步的方法和装置

    公开(公告)号：US07542800B2

    公开(公告)日：2009-06-02

    申请号：US11099141

    申请日：2005-04-05

    申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron McCabe ,  Yi Zhang

    发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron McCabe ,  Yi Zhang

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

    摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

    摘要翻译： 神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。 神经刺激脉冲的输送与该定时参考事件同步。 定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与 血流或压力。

    NEUROSTIMULATION SYSTEMS AND METHODS FOR CARDIAC CONDITIONS
    6.
    发明申请
    NEUROSTIMULATION SYSTEMS AND METHODS FOR CARDIAC CONDITIONS 审中-公开
    心脏条件的神经系统和方法

    公开(公告)号：US20080015659A1

    公开(公告)日：2008-01-17

    申请号：US11860936

    申请日：2007-09-25

    申请人： Yi Zhang ,  Anthony Caparso ,  Imad Libbus ,  Aaron McCabe ,  Scott Meyer ,  Marina Brockway

    发明人： Yi Zhang ,  Anthony Caparso ,  Imad Libbus ,  Aaron McCabe ,  Scott Meyer ,  Marina Brockway

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36114 ,  A61B5/04012 ,  A61B5/4519 ,  A61N1/3622 ,  A61N1/3627

    摘要： Various embodiments provide an implantable medical device comprising a detector, a neural stimulator, and a controller. The detector is configured to detect a pathological condition indicated for an acute neural stimulation therapy. The neural stimulator is capable of delivering a chronic neural stimulation therapy and the acute neural stimulation therapy. The controller is configured to control the neural stimulator to provide the chronic neural stimulation therapy, receive an indicator from the detector that the pathological condition is detected, and control the neural stimulator to integrate the acute neural stimulation therapy with the chronic neural stimulation therapy in response to the indicator.

    摘要翻译： 各种实施例提供了包括检测器，神经刺激器和控制器的可植入医疗装置。 检测器被配置为检测针对急性神经刺激治疗指示的病理状况。 神经刺激器能够递送慢性神经刺激治疗和急性神经刺激治疗。 控制器被配置为控制神经刺激器以提供慢性神经刺激治疗，从检测器接收到检测到病理状况的指示器，并且控制神经刺激器将急性神经刺激治疗与慢性神经刺激治疗结合起来 到指标。

    Cardiac activation sequence monitoring and tracking
    8.
    发明授权
    Cardiac activation sequence monitoring and tracking 有权
    心脏激活序列监测和跟踪

    公开(公告)号：US07890159B2

    公开(公告)日：2011-02-15

    申请号：US10955397

    申请日：2004-09-30

    申请人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

    发明人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

    IPC分类号： A61B5/0428 ,  A61B5/0452

    CPC分类号： A61B5/04011 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

    Wireless ECG in implantable devices
    9.
    发明授权
    Wireless ECG in implantable devices 有权
    无线心电图在植入式设备

    公开(公告)号：US07818051B2

    公开(公告)日：2010-10-19

    申请号：US11925657

    申请日：2007-10-26

    申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

    发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

    摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

    摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

    Wireless ECG in implantable devices
    10.
    发明授权
    Wireless ECG in implantable devices 有权
    无线心电图在植入式设备

    公开(公告)号：US07299086B2

    公开(公告)日：2007-11-20

    申请号：US10795126

    申请日：2004-03-05

    申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

    发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

    IPC分类号： A61B5/0428 ,  A61N1/368

    CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

    摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

    摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。