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1.发明申请METHOD FOR PREDICTING THE OFF-TARGET BIDING OF A PEPTIDE WHICH BINDS TO A TARGET PEPTIDE PRESENTED BY A MAJOR HISTOCOMPATIBILITY COMPLEX 审中-公开用于预测由主要组氨酸复合物呈递给目标肽的肽的非目标定位的方法公开(公告)号：US20150284877A1
公开(公告)日：2015-10-08
申请号：US14741828
申请日：2015-06-17
CPC分类号： G16B35/00 , G01N33/505 , G01N33/6866 , G01N33/6878 , G01N2333/57 , G01N2333/70539 , G01N2500/04 , G16C20/60
摘要： The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
摘要翻译： 本发明提供了一种用于预测与主要组织相容性复合体（MHC）呈递并且用于给予受试者的靶肽结合的结合肽是否具有与受试者体内另外的肽交叉反应的潜力的方法。 该方法包括鉴定结合肽所结合的靶肽中的至少一个结合基序的步骤; 并搜索存在于受试者中的包含至少一个结合基序而不是靶肽的肽。 一种或多种这样的肽的存在表明结合肽具有在体内交叉反应的潜力。
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公开(公告)号：US20210241854A1
公开(公告)日：2021-08-05
申请号：US17158940
申请日：2021-01-26
摘要： The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
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公开(公告)号：US20240312566A1
公开(公告)日：2024-09-19
申请号：US18433344
申请日：2024-02-05
CPC分类号： G16B35/20 , G01N33/505 , G01N33/6866 , G01N33/6878 , G16B35/00 , G16C20/60 , G01N2333/57 , G01N2333/70539 , G01N2500/04
摘要： The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
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