公开(公告)号：US20070014840A1

公开(公告)日：2007-01-18

申请号：US10512486

申请日：2002-04-26

申请人： In-kyu Lee ,  Ryuichi Morishita

发明人： In-kyu Lee ,  Ryuichi Morishita

IPC分类号： A61K48/00 ,  A61K9/127 ,  C07H21/04

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/13 ,  C12N2310/53

摘要： The present invention provides a circular dumbbell oligodeoxynucleotide (CDODN) comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of a transcriptional factor. The present invention further provides a pharmaceutical composition comprising said CDODN. The pharmaceutical composition can be used for treating and/or preventing a disease or disorder related to such a transcriptional factor. The present invention also provides a method for treating and/or preventing a disease or disorder related to such a transcriptional factor, comprising administering to the subject a therapeutically effective amount of a CDODN comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of the transcriptional factor.

摘要翻译： 本发明提供了包含两个环结构和茎结构的环状哑铃寡脱氧核苷酸（CDODN），其中所述茎结构包含能够结合转录因子的DNA结合结构域的核苷酸序列。 本发明还提供了包含所述CDODN的药物组合物。 药物组合物可用于治疗和/或预防与这种转录因子相关的疾病或病症。 本发明还提供了用于治疗和/或预防与这种转录因子相关的疾病或病症的方法，包括向受试者施用治疗有效量的包含两个环结构和茎结构的CDODN，其中茎结构包括 能够结合转录因子的DNA结合结构域的核苷酸序列。