公开(公告)号：US09249206B2

公开(公告)日：2016-02-02

申请号：US13728110

申请日：2012-12-27

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. DiMarchi ,  Brian P. Ward

IPC: A61K38/26 ,  A61P3/10 ,  C07K14/605 ,  A61K38/00

CPC classification number: C07K14/605 ,  A61K38/00

Abstract: Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.

公开(公告)号：US09587005B2

公开(公告)日：2017-03-07

申请号：US14981187

申请日：2015-12-28

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. DiMarchi ,  Brian P. Ward

IPC: A61K38/00 ,  A61K38/26 ,  C07K14/605

CPC classification number: C07K14/605 ,  A61K38/00

Abstract: Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.

Abstract translation: 本文提供了在GIP受体上表现出有效活性的胰高血糖素类似物，并且因此被预期用于治疗糖尿病和肥胖症。 在示例性实施方案中，本公开的胰高血糖素类似物在GIP受体下显示EC50，其在纳摩尔或皮摩尔范围内。

公开(公告)号：US20160115215A1

公开(公告)日：2016-04-28

申请号：US14981187

申请日：2015-12-28

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. Dimarchi ,  Brian P. Ward

IPC: C07K14/605

CPC classification number: C07K14/605 ,  A61K38/00

Abstract: Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.