公开(公告)号：US20250152733A1

公开(公告)日：2025-05-15

申请号：US18837694

申请日：2023-02-08

Applicant: Indiana University Research and Technology Corporation

Inventor： Yan Yu ,  Jared T. Wiemann ,  Swagata Bhattacharyya

IPC: A61K47/69 ,  A61P31/04

Abstract: “Two-faced” amphiphilic Janus nanoparticles that have different surface chemistries on two hemispheres. One hemisphere of the Janus nanoparticles is functionalized with a hydrophobic moiety. The other hemisphere of the nanoparticles is functionalized with either a cationic antibiotic or cationic polymer. Janus nanoparticles effectively inhibit the growth of both Gram-negative and Gram-positive bacteria at picomolar concentrations and may be used as a broad-spectrum antibiotic on surfaces or to treat bacterial infections in patients.