公开(公告)号：US20170320966A1

公开(公告)日：2017-11-09

申请号：US15589191

申请日：2017-05-08

Applicant: Industrial Technology Research Institute

Inventor： Chia-Yu FAN ,  Min-Yuan CHOU

IPC: C07K16/46 ,  A61K39/44 ,  C07K16/18 ,  C07K19/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/46 ,  A61K39/0011 ,  A61K39/44 ,  A61K2039/5152 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2896 ,  C07K16/462 ,  C07K19/00 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: A humanized monoclonal antibody against the CD34 surface antigen is provided in the present disclosure. The humanized monoclonal antibody includes a light chain variable region and a heavy chain variable region. In which, a nucleotide sequence encoding the amino acid sequence for the light chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 9 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 9, and a nucleotide sequence encoding the amino acid sequence for the heavy chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 10 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 10.