公开(公告)号：US20210230600A1

公开(公告)日：2021-07-29

申请号：US17132793

申请日：2020-12-23

Applicant: Industrial Technology Research Institute

Inventor： Ping-Fu CHENG ,  Ya-Ling CHIU ,  Kang-Li WANG ,  Po-Yen LIN ,  Shih-Ta CHEN ,  Tseng-Huang LIU ,  Pei-Shin JIANG

IPC: C12N15/115 ,  C12N15/113 ,  A61K47/54 ,  A61K9/00 ,  A61P35/00

Abstract: A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.