公开(公告)号：US20180110731A1

公开(公告)日：2018-04-26

申请号：US15788920

申请日：2017-10-20

Applicant: Industrial Technology Research Institute

Inventor： Wen-Hsuan CHIANG ,  Yu-Wen LO ,  Felice CHENG ,  Maggie LU ,  Ya-Ling CHIU

IPC: A61K9/06 ,  A61K47/10 ,  A61K47/34 ,  C07K16/32 ,  A61K33/30 ,  A61K39/395 ,  A61K38/26 ,  A61K38/38 ,  A61K38/17 ,  A61K31/704

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/704 ,  A61K33/30 ,  A61K38/1793 ,  A61K38/26 ,  A61K38/385 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/10 ,  A61K47/34 ,  A61K47/42 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/94

Abstract: A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.