公开(公告)号：US20220016042A1

公开(公告)日：2022-01-20

申请号：US17411591

申请日：2021-08-25

申请人： Infectious Disease Research Institute

发明人： Neal VAN HOEVEN ,  Traci MIKASA ,  Christopher B. FOX ,  Anwar AHNIYAZ ,  Mark T. ORR ,  Amit KHANDHAR

IPC分类号： A61K9/51 ,  A61K9/127 ,  A61K39/39

摘要： Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle ranges from about 1 nm to 450 nm. Such a nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.