公开(公告)号：US20150182612A1

公开(公告)日：2015-07-02

申请号：US14419477

申请日：2013-08-02

Applicant: Infectious Disease Research Institute

Inventor： Steven G. Reed ,  Rhea N. Coler

IPC: A61K39/04 ,  A61K39/39 ,  A61K45/06

CPC classification number: A61K39/04 ,  A61K31/4409 ,  A61K31/496 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/70 ,  A61K2300/00

Abstract: The present disclosure relates to methods and compositions for treating a active tuberculosis infection and methods and compositions for improving the efficacy of chemotherapy regimens against active tuberculosis infection. The present disclosure relates to methods of treating an active M. tuberculosis infection or an active infection resulting from reactivation of a latent infection in a mammal and to methods of improving the efficacy of chemotherapy regimens against active M. tuberculosis infection.

Abstract translation: 本公开涉及用于治疗活动性结核感染的方法和组合物，以及用于改善针对活动性结核感染的化疗方案的功效的方法和组合物。 本公开涉及治疗活动性结核分枝杆菌感染或由哺乳动物的潜伏感染的再活化引起的活性感染的方法以及提高针对活动性结核分枝杆菌感染的化学疗法疗效的方法。

公开(公告)号：US20200038498A1

公开(公告)日：2020-02-06

申请号：US16126285

申请日：2018-09-10

Applicant: Infectious Disease Research Institute

Inventor： Steven G. Reed ,  Rhea N. Coler

IPC: A61K39/04 ,  A61K31/4409 ,  A61K31/496 ,  A61K39/39 ,  A61K45/06

Abstract: The present disclosure relates to methods and compositions for treating a active tuberculosis infection and methods and compositions for improving the efficacy of chemotherapy regimens against active tuberculosis infection. The present disclosure relates to methods of treating an active M. tuberculosis infection or an active infection resulting from reactivation of a latent infection in a mammal and to methods of improving the efficacy of chemotherapy regimens against active M. tuberculosis infection.

公开(公告)号：US11091521B2

公开(公告)日：2021-08-17

申请号：US15815512

申请日：2017-11-16

Applicant: Infectious Disease Research Institute

Inventor： Steven G. Reed ,  Rhea N. Coler ,  Gregory C. Ireton ,  Sylvie Bertholet

IPC: C07K14/35 ,  A61K39/04 ,  C07K14/285 ,  A61K39/00 ,  G01N33/569 ,  G01N33/68

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

公开(公告)号：US20200148729A1

公开(公告)日：2020-05-14

申请号：US16098911

申请日：2017-05-19

Applicant: Infectious Disease Research Institute

Inventor： Rhea N. Coler

IPC: C07K14/35 ,  A61K39/04

Abstract: Provided herein are fusion polypeptides comprising at least two Mycobacterial antigens, wherein one Mycobacterial antigen is a strong central memory T cell activator, and wherein one Mycobacterial antigen is a strong effector memory T cell activator. Also provided herein are methods of making and using such fusion polypeptides for the prevention or treatment of a secondary Mycobacterium tuberculosis infection as well as for the prevention or treatment of a nontuberculous Mycobacterium infection in a mammal.

公开(公告)号：US20130209500A1

公开(公告)日：2013-08-15

申请号：US13791511

申请日：2013-03-08

Applicant: Infectious Disease Research Institute

Inventor： Steven G. REED ,  Rhea N. Coler ,  Gregory C. Ireton

IPC: C07K14/35 ,  G01N33/68

CPC classification number: C07K14/35 ,  A61K39/04 ,  A61K2039/55561 ,  C07K14/285 ,  C07K2319/00 ,  G01N33/5695 ,  G01N33/68 ,  G01N2469/20 ,  Y02A50/41 ,  Y02A50/55

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

Abstract translation: 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这种组合物的多核苷酸和融合蛋白。 本发明还涉及其用于治疗，预防和/或诊断结核病感染的方法。

公开(公告)号：US09822152B2

公开(公告)日：2017-11-21

申请号：US13791511

申请日：2013-03-08

Applicant: Infectious Disease Research Institute

Inventor： Steven G. Reed ,  Rhea N. Coler ,  Gregory C. Ireton

IPC: C07K14/35 ,  G01N33/68 ,  A61K39/04 ,  C07K14/285 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K14/35 ,  A61K39/04 ,  A61K2039/55561 ,  C07K14/285 ,  C07K2319/00 ,  G01N33/5695 ,  G01N33/68 ,  G01N2469/20 ,  Y02A50/41 ,  Y02A50/55

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.