公开(公告)号：US11141377B2

公开(公告)日：2021-10-12

申请号：US16622908

申请日：2018-06-15

Applicant: Infectious Disease Research Institute

Inventor： Christopher B. Fox ,  Amit Praful Khandhar ,  Neal Van Hoeven ,  Jesse H. Erasmus ,  Susan S. Lin

IPC: A61K9/107 ,  A61K39/39 ,  A61K9/127 ,  A61K47/10 ,  A61K31/713 ,  A61K47/26 ,  A61K45/06

Abstract: Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.

公开(公告)号：US11266602B2

公开(公告)日：2022-03-08

申请号：US16098619

申请日：2017-05-15

Applicant: Infectious Disease Research Institute ,  University of Virginia Patent Foundation

Inventor： Christopher B. Fox ,  Susan S. Lin ,  Darrick Carter ,  Neal Van Hoeven ,  Mayuresh M. Abhyankar ,  William A. Petri

IPC: A61K9/127 ,  A61K31/739 ,  A61K39/39 ,  A61K39/00

Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.

公开(公告)号：US20220160632A1

公开(公告)日：2022-05-26

申请号：US17560594

申请日：2021-12-23

Applicant: Infectious Disease Research Institute ,  University of Virginia Patent Foundation

Inventor： Christopher B. Fox ,  Susan S. Lin ,  Darrick Carter ,  Neal Van Hoeven ,  Mayuresh M. Abhyankar ,  William A. Petri

IPC: A61K9/127 ,  A61K31/739 ,  A61K39/39

Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.