利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.031 seconds)

    Inhibitors of fatty acid amide hydrolase
    6.
    发明授权
    Inhibitors of fatty acid amide hydrolase 有权
    脂肪酸酰胺水解酶抑制剂

    公开(公告)号：US08629125B2

    公开(公告)日：2014-01-14

    申请号：US13662268

    申请日：2012-10-26

    Applicant: Infinity Pharmaceuticals, Inc.

    Inventor： Julian Adams ,  Mark L. Behnke ,  Alfredo C. Castro ,  Catherine A. Evans ,  Louis Grenier ,  Michael J. Grogan ,  Tao Liu ,  Daniel A. Snyder ,  Thomas T. Tibbitts

    IPC: A61K31/69 ,  A61P25/00 ,  A61P25/06 ,  C07F5/02

    CPC classification number: C07F5/025 ,  A61K31/69 ,  C07F5/05

    Abstract: The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.

    Abstract translation: 本发明提供由式（I），（II）或（III）包含的化合物及其药物组合物。 本发明还提供了通过向患者施用治疗有效量的所提供的式（I），（II）或（III）化合物或其药物组合物来治疗FAAH介导的疾病，病症或病症的方法。 需要它。 此外，本发明提供了通过向有需要的患者施用治疗有效量的式（I），（II）或（III）化合物或其药物组合物来抑制患者的FAAH的方法。

    INHIBITORS OF FATTY ACID AMIDE HYDROLASE
    7.
    发明申请
    INHIBITORS OF FATTY ACID AMIDE HYDROLASE 有权
    脂肪酸酰胺水解酶抑制剂

    公开(公告)号：US20130338107A1

    公开(公告)日：2013-12-19

    申请号：US13970495

    申请日：2013-08-19

    Applicant: INFINITY PHARMACEUTICALS, INC.

    Inventor： Alfredo C. Castro ,  Catherine A. Evans ,  Louis Grenier ,  Michael J. Grogan

    IPC: C07F5/02

    CPC classification number: C07F5/025

    Abstract: Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2 R3, R4, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention.

    Abstract translation: 本文提供式（I）化合物或其药学上可接受的盐，溶剂合物或前药或其混合物，其中Z1，Z2，X1，X2，X3，R1，R2，R3，R4，m和n如本文所定义。 还提供了药学上可接受的组合物，其包括式I化合物和药学上可接受的赋形剂。 还提供了用于治疗FAAH介导的病症的方法，包括向有需要的受试者施用治疗有效量的本发明的化合物或组合物。

    INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME
    10.
    发明申请
    INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME 审中-公开
    脂肪酸酰胺水解酶抑制剂，治疗方法及其制备方法

    公开(公告)号：US20150344503A1

    公开(公告)日：2015-12-03

    申请号：US14828318

    申请日：2015-08-17

    Applicant: Infinity Pharmaceuticals, Inc.

    Inventor： Julian Adams ,  Mark L. Behnke ,  Alfredo C. Castro ,  Catherine A. Evans ,  Louis Grenier ,  Michael J. Grogan ,  Tao Liu ,  Daniel A. Snyder ,  Thomas T. Tibbitts

    IPC: C07F5/02 ,  C07F5/05

    CPC classification number: C07F5/025 ,  A61K31/69 ,  C07F5/05

    Abstract: The present invention provides compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). Methods of preparing compounds encompassed by the formulae (I), (II) or (III) are also provided. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.

    Abstract translation: 本发明提供式（I），（II）或（III）所包含的化合物及其药物组合物。 还提供了制备式（I），（II）或（III）所包括的化合物的方法。 本发明还提供了通过向患者施用治疗有效量的所提供的式（I），（II）或（III）化合物或其药物组合物来治疗FAAH介导的疾病，病症或病症的方法。 需要它。 此外，本发明提供了通过向有需要的患者施用治疗有效量的式（I），（II）或（III）化合物或其药物组合物来抑制患者的FAAH的方法。

Patent Agency Ranking