公开(公告)号：US20240300898A1

公开(公告)日：2024-09-12

申请号：US18665214

申请日：2024-05-15

Applicant: InflaRx GmbH

Inventor： YONG LI ,  RENFENG GUO ,  NIELS CHRISTOPH RIEDEMANN

IPC: C07D215/54 ,  C07D405/12

CPC classification number: C07D215/54 ,  C07D405/12

Abstract: The present invention relates to fused piperidinyl bicyclic, meta-substituted piperidinyl and their related compounds that modulate activities of mammalian C5a receptor by directly binding to the C5a receptor. The invention also relates to pharmaceutical compositions containing such compounds and their use in the treatment of a disease or a disorder involving pathogenic activation of C5a receptors.

公开(公告)号：US20200290969A1

公开(公告)日：2020-09-17

申请号：US16784951

申请日：2020-02-07

Applicant: InflaRx GmbH

Inventor： YONG LI ,  RENFENG GUO ,  NIELS CHRISTOPH RIEDEMANN

IPC: C07D215/54 ,  C07D405/12

Abstract: The present invention relates to fused piperidinyl bicyclic, meta-substituted piperidinyl and their related compounds that modulate activities of mammalian C5a receptor by directly binding to the C5a receptor. The invention also relates to pharmaceutical compositions containing such compounds and their use in the treatment of a disease or a disorder involving pathogenic activation of C5a receptors.

公开(公告)号：US20210403433A1

公开(公告)日：2021-12-30

申请号：US17470980

申请日：2021-09-09

Applicant: InflaRx GmbH

Inventor： YONG LI ,  RENFENG GUO ,  NIELS CHRISTOPH RIEDEMANN

IPC: C07D215/54 ,  C07D405/12

Abstract: The present invention relates to fused piperidinyl bicyclic, meta-substituted piperidinyl and their related compounds that modulate activities of mammalian C5a receptor by directly binding to the C5a receptor. The invention also relates to pharmaceutical compositions containing such compounds and their use in the treatment of a disease or a disorder involving pathogenic activation of C5a receptors.