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公开(公告)号：US20240024476A1
公开(公告)日：2024-01-25
申请号：US18260376
申请日：2022-01-06
发明人： Chengfei Pu , Zhiyuan Cao , Xiaogang Shen , Wensheng Wang , Beibei Jia , Dongqi Chen , Xiaoqiang Xu , Xudong Tang , Wei Ding , Xianyang Jiang , Yuzhe Peng , Guiting Han , Le Tian , Zhao Wu , Lei Xiao
IPC分类号： A61K39/00 , C07K14/725 , C12N5/0783 , C07K16/30 , C07K16/28 , C07K16/18 , C07K16/40 , A61P35/00
CPC分类号： A61K39/4631 , C07K14/7051 , C12N5/0636 , C07K16/3023 , C07K16/303 , C07K16/2875 , C07K16/2803 , C07K16/28 , C07K16/2851 , C07K16/18 , C07K16/40 , A61P35/00 , A61K39/4611 , A61K39/4644 , A61K39/464474 , A61K39/464417 , A61K39/464402 , A61K39/464458 , A61K39/464411 , C07K2319/03 , C07K2319/33 , C07K2317/622 , A61K2239/13 , C07K2317/31
摘要： The compositions and methods described herein are directed to treating solid tumor using CAR T therapy. For example, the compositions include CAR T cells comprising an extracellular domain that binds FCR1, MSLN, GPC-3, ALPP, CD70, CLDN6, ROR1, CD205, ACPP, ADAM12, or CLDN18.2.
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公开(公告)号：US20230032871A1
公开(公告)日：2023-02-02
申请号：US17812521
申请日：2022-07-14
发明人： Zhiyuan Cao , Wei Ding , Guiting Han , Lei Xiao , Le Tian
IPC分类号： A61K31/519 , A61K38/17 , A61K38/21 , A61K38/20 , A61K38/19
摘要： The present disclosure relates to systems and methods for immune therapy. For example, a method can be used to enhance proliferation of chimeric antigen receptor (CAR) T cells in a patient, The method comprises administering to the patient an effective amount of a pharmaceutical composition comprising lymphocyte activation agents and one or more recombinant viral particles comprising a polynucleotide encoding a CAR, wherein the proliferation of CAR T cells in the patient is greater as compared to a patient administered with the one or more recombinant viral particles but without the lymphocyte activation agents.
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