公开(公告)号：US20220246235A1

公开(公告)日：2022-08-04

申请号：US17726250

申请日：2022-04-21

Applicant: Inscripta, Inc.

Inventor： Andrea HALWEG-EDWARDS ,  Joshua SHORENSTEIN ,  Andrew GARST ,  Craig STRUBLE ,  Miles GANDER ,  Juhan KIM ,  Bryan LELAND ,  Eileen SPINDLER ,  Paul HARDENBOL ,  Aaron BROOKS ,  Eric ABBATE

IPC: G16B20/30 ,  G16B40/20 ,  C12N15/10 ,  G06N3/08

Abstract: The present disclosure is drawn to creating cassette designs for nucleic acid-guided nuclease editing. In designing editing cassettes, a set of edit specifications must first be obtained. These edit specifications are taken together with a set of configuration parameters to start a computational pipeline that generates a collection of cassette designs. The process of designing editing cassettes involves the following exemplary steps: 1) creation of a set of candidate cassette designs for each unique edit specification, 2) enumeration of features describing biophysical characteristics of each candidate design, 3) providing each candidate design with a score, and 4) returning a number of scored and rank-ordered candidate cassette designs for each edit specification.

公开(公告)号：US20240425834A1

公开(公告)日：2024-12-26

申请号：US18685686

申请日：2022-08-24

Applicant: Inscripta, Inc.

Inventor： Eric ABBATE ,  Katherine KROUSE ,  Aaron BROOKS ,  Tyson SHEPHERD ,  Nandini KRISHNAMURTHY

IPC: C12N9/42 ,  C07K14/395

Abstract: The present disclosure relates to various different types of mutations or modifications in Saccharomyces cerevisiae coding and noncoding regions leading to enhanced cellobiohydrolase I production for, e.g., supplements and nutraceuticals.