公开(公告)号：US11174220B2

公开(公告)日：2021-11-16

申请号：US17119527

申请日：2020-12-11

申请人： Inspirna, Inc.

发明人： Stephen Wald ,  Eduardo J. Martinez ,  Samuel Stratford ,  Amanda Buist ,  Joseph Benson ,  Jonathan Loughrey

IPC分类号： C07C229/34 ,  A61P35/04

摘要： The present invention relates to metal salts of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid which exhibit improved physical properties and stability. The invention also relates to pharmaceutical compositions including an effective amount of the metal salts, as well as methods of treating cancer including administration of a pharmaceutical composition including a salt of the invention to a subject in need thereof.

公开(公告)号：US11878956B2

公开(公告)日：2024-01-23

申请号：US17821699

申请日：2022-08-23

申请人： Inspirna, Inc.

发明人： Stephen Wald ,  Eduardo J. Martinez ,  Samuel Stratford ,  Amanda Buist ,  Joseph Benson ,  Jonathan Loughrey

IPC分类号： C07C229/34 ,  A61P35/04

CPC分类号： C07C229/34 ,  A61P35/04

摘要： The present invention relates to metal salts of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid which exhibit improved physical properties and stability. The invention also relates to pharmaceutical compositions including an effective amount of the metal salts, as well as methods of treating cancer including administration of a pharmaceutical composition including a salt of the invention to a subject in need thereof.

公开(公告)号：US11459292B2

公开(公告)日：2022-10-04

申请号：US17407394

申请日：2021-08-20

申请人： Inspirna, Inc.

发明人： Stephen Wald ,  Eduardo J. Martinez ,  Samuel Stratford ,  Amanda Buist ,  Joseph Benson ,  Jonathan Loughrey

IPC分类号： C07C229/34 ,  A61P35/04

摘要： The present invention relates to metal salts of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid which exhibit improved physical properties and stability. The invention also relates to pharmaceutical compositions including an effective amount of the metal salts, as well as methods of treating cancer including administration of a pharmaceutical composition including a salt of the invention to a subject in need thereof.