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公开(公告)号:US09186423B1
公开(公告)日:2015-11-17
申请号:US14492174
申请日:2014-09-22
发明人: Wuu-Jyh Lin , Shiou-Shiow Farn , Yean-Hung Tu , Li-Yuan Huang , Dow-Che Chen , Kuo-Yuan Chu , Mao-Hsung Chang , Ting-Shien Duh , Jenn-Tzong Chen , Chyng-Yann Shiue
IPC分类号: C07C211/00 , A61K51/04
CPC分类号: A61K51/04 , C07C255/42
摘要: A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.
摘要翻译: 提供了一种用于tau蛋白的放射性对比剂。 该药物选择性地和强烈地结合在脑疾病如阿尔茨海默病(AD)中发现的tau蛋白及其缠结。 该药剂特别适合用于脑部疾病的PET成像。 或者,该药物可用于抑制tau蛋白过表达,从而阻止脑疾病的进行。